WormBook is the online review of C. elegans biology and serves as a text companion to WormBase, the comprehensive nematode genomics and proteomics information resource. en-us wormbook-help@wormbase.org (WormBook Help Desk) mendelj@caltech.edu (Jane Mendel) Copyright © 2005, 2006, 2007, 2008 WormBook. All WormBook content, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fri, 25 Jan 2008 23:30:50 GMT 360 http://www.wormbook.org A new issue of The Worm Breeder's Gazette is now available at http://www.wormbook.org/wbg/. This issue includes 25 contributions describing new methods for selecting transformants, useful strains and vectors, bioinformatics resources, visualization methods and more. Thu, 17 June 2010 19:36:50 GMT http://www.wormbook.org/wbg/ http://www.wormbook.org/wbg/ Ethanol, by Steven McIntire, is now available in html and pdf formats. Sun, 2 May 2010 19:36:50 GMT http://www.wormbook.org/chapters/www_ethanol/ethanol.html http://www.wormbook.org/chapters/www_ethanol/ethanol.html 'Molecular evolution inferences from the C. elegans genome' by Asher Cutter has been added to the Evolution and ecology section. This chapter discusses mutation, recombination, natural selection, genetic drift and population dynamics in C. elegans. Fri, 5 Mar 2010 19:36:50 GMT http://wormbook.org/chapters/www_molecularevol/molecularevol.html http://wormbook.org/chapters/www_molecularevol/molecularevol.html 'Transgenic solutions for the germline' by Cristopher Merritt and Geraldine Seydoux has been added to the Transformation and microinjection section of WormMethods. This chapter gives advice and protocols for designing and transforming germline-expressing transgenes. Thu, 18 Jan 2010 20:03:50 GMT http://wormbook.org/chapters/www_transgenic/transgenic.html http://wormbook.org/chapters/www_transgenic/transgenic.html The first issue of The Worm Breeder’s Gazette in its new on-line format is now available online. This issue includes over 30 contributions on diverse topics including an editorial by Marty Chalfie, information on a common background mutation, new ways to visualize molecules, and several new techniques. We thank the authors and the worm community for their enthusiastic response to the revival of The Worm Breeder’s Gazette. Tue, 15 Dec 2009 23:30:50 GMT http://www.wormbook.org/wbg/ http://www.wormbook.org/wbg/ *** Due to server maintenance, WormBook pages may be unavailable on Wednesday September 9th, 1-5pm EDT. *** Tue, 09 Sep 2009 16:30:50 GMT http://www.wormbook.org/ http://www.wormbook.org/ 'Autophagy' by Alicia Melendez and Beth Levine has been published in the Cell biology section of WormBook. This chapter details the evolutionarily conserved features autophagy in C. elegans, and describes the role of autophagy in several aspects of C. elegans biology including survival during starvation, dauer and reproductive development, lifespan extension, programmed and necrotic cell death, and neurodegenerative diseases. Mon, 24 Aug 2009 16:30:50 GMT http://www.wormbook.org/chapters/www_autophagy/autophagy.html http://www.wormbook.org/chapters/www_autophagy/autophagy.html A new chapter 'Intermediary metabolism' has been added to the Biochemistry section of WormBook. This chapter, by Bart Braeckman, Koen Houthoofd and Jacques Vanfleteren, describes the major metabolic pathways in C. elegans, and discusses how metabolic activity changes in response to development, aging and environmental stress. Mon, 26 Feb 2009 16:30:50 GMT http://www.wormbook.org/chapters/www_intermetabolism/intermetabolism.html http://www.wormbook.org/chapters/www_intermetabolism/intermetabolism.html WormBook Editor-in-Chief Martin Chalfie (with Osamu Shimomura and Roger Y. Tsien) has won the 2008 Nobel Prize in Chemistry for pioneering the use of GFP in C. elegans. This is the third Nobel Prize awarded for research on C. elegans in the last six years. Congratulations to Martie! Wed, 8 Oct 2008 16:30:50 GMT http://nobelprize.org/nobel_prizes/chemistry/laureates/2008/index.html http://nobelprize.org/nobel_prizes/chemistry/laureates/2008/index.html SNPs: introduction and 2-point mapping by David Fay has been updated in the Forward genetics and genetic mapping section of WormMethods. This updated chapter includes expanded instruction on the use of SNP databases and additional graphics related to SNP mapping. Fri, 26 Sep 2008 11:30:50 GMT http://www.wormbook.org/chapters/www_SNPsintrotwopointmap.2/SNPsintrotwopointmap.html http://www.wormbook.org/chapters/www_SNPsintrotwopointmap.2/SNPsintrotwopointmap.html Neuropeptides has been added to the Neurotransmitters section of Neurobiology and behavior. This chapter provides comprehensive coverage of all aspects of neuropeptide biology in C. elegans as well as extensive tables detailing peptide sequences, expression patterns and functions. Fri, 26 Sep 2008 10:30:50 GMT http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html Germline survival and apoptosis chapter has been added to The germ line section. WormBook readers are welcome to read the new chapter and post feedbacks at the WormBook forum. Tue, 9 Sep 2008 23:30:50 GMT http://www.wormbook.org/chapters/www_germlinesurvival/germlinesurvival.html http://www.wormbook.org/chapters/www_germlinesurvival/germlinesurvival.html Links to the WormBook discussion forum now appear on each chapter page. Clicking 'View/Add Comments' will take you to a new chapter level folder in the discussion board. If you would like to be notified when new comments are posted to a particular chapter, please login and then use the ‘NOTIFY’ button on the chapter level. Please register or log in and let us know what you think. Tue, 13 May 2008 23:35:50 GMT http://www.wormbase.org/forums/index.php?board=31.0 http://www.wormbase.org/forums/index.php?board=31.0 WormBook chapters are now easier to read online because all figures have been resized for clarity. Figures can also be further expanded with a simple mouse click. Tue, 13 May 2008 23:30:50 GMT http://www.wormbook.org/ http://www.wormbook.org/ The measurement and analysis of age-related changes in Caenorhabditis elegans is now available in the Post-embryonic development section of WormBook. Please visit this chapter to read about aging in C. elegans. Fri, 25 Jan 2008 23:30:50 GMT http://www.wormbook.org/chapters/www_measurementanalysisCelegans/measurementanalysisCelegans.html http://www.wormbook.org/chapters/www_measurementanalysisCelegans/measurementanalysisCelegans.html We are pleased to announce that most WormBook chapters are now indexed in PubMed. Abstracts are linked directly to the full text at WormBook. Thu, 24 Jan 2008 23:30:50 GMT http://www.ncbi.nlm.nih.gov/sites/entrez http://www.ncbi.nlm.nih.gov/sites/entrez Anthelmintic drugs has just been published in the Disease models and drug discovery section of WormBook. This chapter summarizes the modes of action of the main classes of anthelmintic drugs, their utility in studying cell signaling in C. elegans, and the use of C. elegans in drug discovery programs. Fri, 2 Nov 2007 23:30:50 GMT http://www.wormbook.org/chapters/www_anthelminticdrugs/anthelminticdrugs.html http://www.wormbook.org/chapters/www_anthelminticdrugs/anthelminticdrugs.html Dauer has just been published in the Post-embryonic development section of WormBook. Please visit this section to read about the signaling pathways and molecular mechanisms regulating dauer arrest. Thu, 9 Aug 2007 23:30:50 GMT http://www.wormbook.org/chapters/www_dauer/dauer.html http://www.wormbook.org/chapters/www_dauer/dauer.html Tristan Fiedler, who led the software development group at WormBook, has left WormBook. He has taken a faculty position at the Florida Institute of Technology. Tristan guided the development of every aspect of the web site. He developed the methods to convert manuscripts to web-ready articles; he designed the initial layout of the web site; and he generated the programs to search WormBook, download reference citations, and provide feedback. His input on all aspects of WormBook will be missed. Mon, 6 Aug 2007 21:30:50 GMT http://www.wormbook.org/index.html#newsfront http://www.wormbook.org/index.html#newsfront We are fortunate that Jane Mendel has joined us as the new WormBook Editor. Jane, a WormBook author, is a Senior Research Associate and Lecturer at Caltech, and has a strong background in C. elegans research as well as experience in teaching Introductory Biology and in using C. elegans as a teaching tool. Mon, 30 Jul 2007 9:30:50 GMT http://www.wormbook.org/index.html#newsfront http://www.wormbook.org/index.html#newsfront WormBook Editor Lisa Girard has moved to a position at the Harvard Stem Cell Institute. Lisa guided WormBook from its beginning, and her creativity, dedication, and efficiency were essential for its success. Lisa was involved in all aspects of WormBook production: she prodded authors, reviewers, and editorial board members to keep WormBook on schedule, edited and oversaw the publication of 140 articles on the web, and successfully negotiated WormBook's inclusion on the NIH Bookshelf and in PubMed. Lisa leaves WormBook in excellent shape. We wish her continued success in her new position. Mon, 30 Jul 2007 9:30:50 GMT http://www.wormbook.org/index.html#newsfront http://www.wormbook.org/index.html#newsfront Strongyloides spp. has just been published in the Genetics and genomics section of WormBook, further expanding our coverage of parasitic nematodes. Thu, 24 May 2007 19:30:50 GMT http://www.wormbook.org/chapters/www_genomesStrongyloides/genomesStrongyloides.html http://www.wormbook.org/chapters/www_genomesStrongyloides/genomesStrongyloides.html C. elegans and volatile anesthetics is now available in the Disease models and drug discovery section of WormBook. This addition contributes to our coverage of this quickly growing area. Mon, 7 May 2007 19:00:50 GMT http://www.wormbook.org/chapters/www_anesthetics/anesthetics.html http://dev.wormbook.org/chapters/www_anesthetics/anesthetics.html Roles of chromatin factors in C. elegans development has just been added to the Molecular biology section of WormBook and Genomics and biology of the nematode Caenorhabditis briggsae has just been added to the Genetics and genomics section. Please visit these sections to read the latest additions to WormBook. Fri, 4 May 2007 12:50:50 GMT http://www.wormbook.org/chapters/www_chromatinfactors/chromatinfactors.html http://dev.wormbook.org/chapters/www_chromatinfactors/chromatinfactors.html The previously undescribed C. sp. 4 (also known as 'CB5161' or 'PB2801') is now Caenorhabditis brenneri, named after Sydney Brenner (Sudhaus and Kiontke, 2007). Sat, 28 Apr 2007 01:15:50 GMT http://www.mapress.com/zootaxa/2007f/zt01456p062.pdf http://www.mapress.com/zootaxa/2007f/zt01456p062.pdf The C. elegans intestine has just been published in the Developmental control section of WormBook. Please visit this section for coverage of early developmental events. Thu, 29 Mar 2007 18:26:50 GMT http://www.wormbook.org/chapters/www_intestine/intestine.html http://www.wormbook.org/chapters/www_intestine/intestine.html WormBook is pleased to launch its new Disease models and drug discovery section with the publication of Obesity and the regulation of fat metabolism. Please watch for the publication of more chapters in this section describing progress in our understanding of disease and therapeutics. Thu, 29 Mar 2007 17:40:50 GMT http://www.wormbook.org/chapters/www_obesity/obesity.html http://www.wormbook.org/chapters/www_obesity/obesity.html The cuticle has just been published in the Cell biology section of WormBook. Readers are encouraged to visit the Cell biology section to read this chapter and related chapters exploring the cell biology of C. elegans. Thu, 22 Mar 2007 18:49:50 GMT http://www.wormbook.org/chapters/www_cuticle/cuticle.html http://www.wormbook.org/chapters/www_cuticle/cuticle.html Please take a few minutes to complete the WormBook Survey. Your response will help us improve the nature and quality of the service we provide our readers. Mon, 6 Mar 2007 04:49:50 GMT http://dev.wormbase.org/db/surveys/2007_wormbook http://dev.wormbase.org/db/surveys/2007_wormbook WormBook has further expanded its coverage of parasitic nematodes with the addition of The biology and genome of Heterorhabditis bacteriophora. Please visit the Genetics and genomics section of WormBook to read this and other chapters describing the biology and genomes of nematodes other than C. elegans. Sat, 24 Feb 2007 19:38:50 GMT http://www.wormbook.org/chapters/www_genomesHbacteriophora/genomesHbacteriophora.html http://www.wormbook.org/chapters/www_genomesHbacteriophora/genomesHbacteriophora.html Wormbook readers are invited to read our newly added chapter Biogenic amine neurotransmitters in C. elegans in WormBook's Neurobiology and behavior section. Wed, 21 Feb 2007 22:46:50 GMT http://www.wormbook.org/chapters/www_monoamines/monoamines.html http://www.wormbook.org/chapters/www_monoamines/monoamines.html Wormbook readers are invited to read our newly added chapter Strongyloides stercoralis: a model for translational research on parasitic nematode biology in WormBook's WormMethods section. Wed, 21 Feb 2007 22:45:50 GMT http://www.wormbook.org/chapters/www_strongyloides/strongyloides.html http://www.wormbook.org/chapters/www_strongyloides/strongyloides.html 16th International C. elegans Meeting will be held June 27- July 1, 2007 at the University of California, Los Angeles. Meeting information can be found at http://genetics.faseb.org/genetics/Celegans/. The abstract submission site is now open. The deadline for abstract submissions is March 22. The deadline for registration is May 25. Sat, 17 Feb 2007 06:05:50 GMT http://genetics.faseb.org/genetics/Celegans/ http://genetics.faseb.org/genetics/Celegans/ Effective February 22nd 2007, longtime C. elegans researcher Ronald Plasterk will join the Government of the Netherlands, serving as Minister of Education, Science and Culture. Fri, 16 Feb 2007 14:44:50 GMT http://en.wikipedia.org/wiki/Ronald_Plasterk http://en.wikipedia.org/wiki/Ronald_Plasterk The Genetics Society of America's upcoming Genetic Analysis: Model Organisms to Human Biology Meeting will be held January 5-8, 2008 in San Diego, CA at the Town and Country Hotel. Tue, 6 Feb 2007 18:57:50 GMT http://www.genetics-gsa.org/genetics/g-gsa/meetings-mohb.shtml http://www.genetics-gsa.org/genetics/g-gsa/meetings-mohb.shtml Wormbook readers are invited to read our newly added chapter Acetylcholine in WormBook's Neurobiology and behavior section. Tue, 30 Jan 2007 19:59:50 GMT http://www.wormbook.org/chapters/www_acetylcholine/acetylcholine.html http://www.wormbook.org/chapters/www_acetylcholine/acetylcholine.html A set of instructions for importing the entire WormBook reference set into Endnote v. 8 has been added to the WormBook website. Fri, 26 Jan 2007 22:14:50 GMT http://www.wormbook.org/endnote/#v8 http://www.wormbook.org/endnote/#v8 WormBook now provides an rss feed for worm researchers to remain up-to-date with the rapid addition of new chapters. Wed, 24 Jan 2007 09:00:00 GMT http://www.wormbook.org/rss.xml http://www.wormbook.org/rss.xml The C. elegans pharynx: a model for organogenesis has been added to the Developmental control section of WormBook. Readers are encouraged to visit this section to read this chapter and others pertaining to early developmental events. Tue, 23 Jan 2007 08:23:48 GMT http://www.wormbook.org/chapters/www_organformation/organformation.html http://www.wormbook.org/chapters/www_organformation/organformation.html The Post-embryonic development section of WormBook has been launched with the publication of Gene expression changes associated with aging in C. elegans. Additional chapters related to the topics of aging and development will be upcoming. Fri, 05 Jan 2007 14:07:22 GMT http://www.wormbook.org/chapters/www_geneexpressionaging/geneexpressionaging.html http://www.wormbook.org/chapters/www_geneexpressionaging/geneexpressionaging.html Wormbook readers are invited to read our last new chapter before 2007 Caenorhabditis briggsae methods in WormBook's WormMethods section. Sun, 31 Dec 2006 23:59:59 GMT http://www.wormbook.org/chapters/www_Cbriggsaemethods/Cbriggsaemethods.html http://www.wormbook.org/chapters/www_Cbriggsaemethods/Cbriggsaemethods.html