CGC Bibliography Paper 4925

Targets of TGF Beta-related signaling in Caenorhabditis elegans.

Savage-Dunn C

Medline:

11544101

Citation:

Cytokine and Growth Factor Reviews 12: 305-312 2001

Type:

REVIEW

Genes:

bra-1 cat-2 daf-1 daf-3 daf-4 daf-5 daf-7 daf-8 daf-12 daf-14 dbl-1 egl-4 egl-32 lin-31 lon-1 myo-2 scd-1 scd-2 scd-3 sma-2 sma-3 sma-4 sma-6 tig-1 unc-129

Abstract:

With the characterization of the Smads 5 years ago, it became possible to trace the TGFB signal transduction pathway from the plasma membrane to the nucleus. Since that time, many Smad interaction partners, cofactors and target genes have been identified using a variety of experimental approaches and model systems. Understanding how these generate tissue specificity and crosstalk between pathways is an ongoing puruit for the field of TGFB signal transduction. The nematode Caenorhabditis elegans provides a simple, genetically tractable model organism in which to address this goal. This review will examine progress towards the identification of cellular and molecular targets of TGFB-related signaling in C. elegans.