CGC Bibliography Paper 4939

Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans.

Johnson TE, de Castro E, de Castro SH, Cypser J, Henderson S, Tedesco P

Medline:

11672983

Citation:

Experimental Gerontology 36: 1609-1617 2001

Type:

ARTICLE

Genes:

age-1 daf-2 daf-4 daf-7 daf-16 daf-23 daf-28 mev-1 old-1 spe-26

Abstract:

We review the status of the hypothesis that interventions that increase the resistance to stress offer the potential for effective life prolongation and increased health. The work focuses on research in the nematode worm Caenorhabditis elegans and describes both published and unpublished results consistent with this hypothesis. Correlations between stress resistance and longevity among many gerontogene mutants is provided.