CGC Bibliography Paper 4967

Functional conservation between the human, nematode, and yeast CK2 cell cycle genes.

Dotan I, Ziv E, Dafni N, Beckman JS, McCann RO, Glover CVC, Canaani D

Medline:
11676486
Citation:
Biochemical and Biophysical Research Communications 288: 603-609 2001
Type:
ARTICLE
Genes:
Abstract:
Protein kinase CK2 (formerly casein kinase II) is a highly conserved serine/threonine protein kinase ubiquitous in eukaryotic organisms. Previously, we have shown that CK2 is required for cell cycle progression and essential for the viability of the yeast Saccharomyces cerevisiae. We now report that either the human or the nematode Caenorhabditis elegans CK2 alpha catalytic subunit can substitute for the yeast catalytic subunits. Additionally, expression of the human CK2 regulatory subunit (CK2 beta) can suppress the temperature sensitivity of either of the two yeast CK2 mutant catalytic subunits. Taken together, these observations reinforce the view that the CK2 cell cycle progression genes have been highly conserved during evolution from yeast to humans, not only in structure but also in function.