CGC Bibliography Paper 4972

Genomic structure of three CLN3-like genes in Caenorhabditis elegans.

Mitchell WA, Porter M, Kuwabara P, Mole SE

Medline:

21473523

Citation:

European Journal of Paediatric Neurology 5SA: 121-125 2001

Type:

ARTICLE

Genes:

Abstract:

The genome of Caenorhabditis elegans is predicted to carry three genes similar to CLN3, the gene underlying juvenile neuronal ceroid lipofuscinosis. All three genes are transcribed and the genomic structure has been determined. The number and position of exons for two of the genes differ from that predicted from the genomic sequence, but no discrepancies with the genomic nucleotide sequence were found. Gene F07B10.1 (cln-3.1) is predicted to have 7 exons and to encode a protein of 424 amino acids. Gene C01G8.2 (cln-3.2) has 9 exons and encodes a protein of 435 amino acids. Gene ZC190.1 (cln-3.3) is predicted to have 9 exons and to encode a protein of 416 amino acids.