CGC Bibliography Paper 4974

Caenorhabditis elegans: how good a model for veterinary parasites?

Geary TG, Thompson DP

Medline:

11707307

Citation:

Veterinary Parasitology 101: 371-386 2001

Type:

ARTICLE

Genes:

Abstract:

The organism about which most is known on a molecular level is a nematode, the free-living organism Caenorhabditis elegans. This organism has served as a reasonable model for the discovery of anthelmintic drugs and for research on the mechanism of action of anthelmintics. Useful information on mechanisms of anthelmintic resistance has also been obtained from studies on C elegans. Unfortunately, there has not been a large-scale extension of genetic techniques developed in C elegans to research on parasitic species of veterinary (or human) parasites. Much can be learned about the essentials of nematode biology by studying C. elegans, but discovering the basic biology of nematode parasitism can only be gained through comparative studies on multiple