CGC Bibliography Paper 4992

Characterization of a cadmium-inducible isoform of pyruvate carboxylase from Caenorhabditis elegans.

Liao VHC, Freedman JH

Medline:

11761713

Citation:

DNA Sequence 12: 137-145 2001

Type:

ARTICLE

Genes:

Abstract:

A homologue of pyruvate carboxylase was isolated as an expressed sequence tag during the identification of cadmium-responsive genes in Caenorhabditis elegans. The C. elegans protein, designated PYC-1, is predicted to contain 1,175 amino acids with a molecular mass of 129,284. Amino acid sequence analysis indicates that PYC-1 will be translocated into mitochondria, FYC-1 has high levels of amino acid sequence identity with other pyruvate carboxylases. The highest levels of identity are in the putative transcarboxylation, biotin carboxylation and biotin carboxyl carrier domains.