CGC Bibliography Paper 5061

Dynamic regulation of axon guidance.

Yu TW, Bargmann CI

Medline:

Citation:

Nature Neuroscience 4: 1169-1176 2001

Type:

REVIEW

Genes:

efn-1 efn-2 efn-3 efn-4 mab-20 plx-1 plx-2 sax-3 slt-1 smp-1 unc-5 unc-6 unc-40 unc-129 unc-130 vab-1 vab-2

Abstract:

To reach their proper targets, axons rely upon the actions of highly conserved families of attractive and repulsive guidance molecules, including the netrins, Slits, semaphorins and ephrins. These guidance systems are used to generate an astonishingly varied set of neuronal circuits. Here we consider the mechanisms by which a few guidance systems can be used to generate diverse outcomes. Recent studies have revealed extensive transcriptional and post-transcriptional regulation of guidance cues and their regulators, as well as combinatorial mechanisms that integrate information from different families of guidance cues.