CGC Bibliography Paper 5082

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.

Goutte C, Tsunozaki M, Hale VA, Priess JR

Medline:

11792846

Citation:

Proceedings of the National Academy of Sciences USA 99: 775-779 2002

Type:

ARTICLE

Genes:

aph-1 aph-2 glp-1 nDf25

Abstract:

Early embryonic cells in Caenorhabditis elegans embryos interact through a signaling pathway closely related to the Notch signaling pathway in Drosophila and vertebrates. Components of this pathway include a ligand, receptor, the presenilin proteins, and a novel protein, APH-2, that is related to the Nicastrin protein in humans. Here we identify the aph-1 gene as a new component of the Notch pathway in Caenorhabditis elegans. aph-1 is predicted to encode a novel, highly conserved multipass membrane protein. We show that aph-1 and the presenilin genes share a similar function in that they are both required for proper cell-surface localization of APH-2/Nicastrin.