CGC Bibliography Paper 5096

Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.

Davis ES, Wille L, Chestnut BA, Sadler PL, Shakes DC, Golden A

Medline:

Citation:

Genetics 160: 805-813 2002

Type:

ARTICLE

Genes:

apc-1 apc-2 apc-4 apc-5 apc-10 apc-11 cdc-16 cdc-23 cdc-27 emb-27 emb-30 evl-22 mat-1 mat-2 mat-3 rec-8

Abstract:

Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis 1, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.