CGC Bibliography Paper 5098

Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase.

Lanjuin A, Sengupta P

Medline:

11832225

Citation:

Neuron 33: 369-381 2002

Type:

ARTICLE

Genes:

daf-5 daf-16 egl-4 kin-29 lim-4 odr-1 odr-4 odr-10 osm-6 sma-11 sns-8 sra-6 sra-9 sre-1 srg-8 srg-13 sro-1 str-1 str-2 str-3 str-219 str-220 tax-4 tph-1 unc-3 unc-14 unc-31 mgDf50

Abstract:

Sensory signals regulate multiple developmental and behavioral circuits in C. elegans, providing a genetically tractable system in which to investigate the mechanisms underlying the acquisition and integration of sensory information. kin-29 mutants are defective in the expression of a set of chemoreceptor genes, and exhibit characteristics associated with altered sensory signaling, including increased lifespan, decreased body size, and deregulated entry into the dauer developmental stage. kin-29 encodes a Ser/Thr kinase with similarity to the MARK and AMPK/SNF1 family of kinases. We show that KIN-29 acts cell-autonomously and non-cell-autonomously in sensory neurons to regulate chemoreceptor expression, body size, and the dauer decision, suggesting that kin-29 function is essential for the correct acquisition and transduction of sensory information.