CGC Bibliography Paper 5110

Of mice and worms: novel insights into ClC-2 anion channel physiology.

Strange K

Medline:

11821530

Citation:

News in Physiological Sciences 17: 11-16 2002

Type:

REVIEW

Genes:

clh-1 clh-2 clh-3 clh-4 clh-5 clh-6

Abstract:

CIC anion channels are found in all major groups of organisms. Recent studies in nematodes and mice suggest that the function and regulation of CIC-2 have been conserved over vast evolutionary time spans. These studies illustrate the experimental advantages of using genomically defined non-mammalian model organisms for characterizing CIC channel functional genomics.