CGC Bibliography Paper 5119

Caenorhabditis elegans as a host for the study of host-pathogen interactions.

Aballay A, Ausubel FM

Medline:

11834377

Citation:

Current Opinion in Microbiology 5: 97-101 2002

Type:

REVIEW

Genes:

age-1 ced-3 ced-4 ced-9 egl-9 egl-19 mev-1 rad-8 srf-2 srf-3 srf-5 unc-43

Abstract:

Recently, pathogenicity models that involve the killing of the genetically tractable nematode Caenorhabditis elegans by human pathogens have been developed. From the perspective of the pathogen, the advantage of these models is that thousands of mutagenized bacteria clones can be individually screened for avirulent mutants on separate petri plates seeded with C. elegans. The advantages of using C. elegans to study host responses to pathogen attack are the extensive genetic and genomic resources available and the relative ease of identifying C. elegans mutants that exhibit altered susceptibility to pathogen attack. The use of Caenorhabditis elegans as the host for a variety of human pathogens is discussed.