CGC Bibliography Paper 5136

Caenorhabditis elegans unc-37/groucho interacts genetically with components of the transcriptional mediator complex.

Zhang H, Emmons SW

Medline:

Citation:

Genetics 160: 799-803 2002

Type:

ARTICLE

Genes:

bar-1 egl-5 lin-22 lin-32 mab-5 pal-1 sop-1 sop-3 sur-2 unc-37

Abstract:

Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcriptional Mediator complex, resulting in synthetic lethality and loss of male sensory neurons.