Worm Breeder's Gazette 17(2): 46 (April 1, 2002)
These abstracts should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the author.
| 1 | Box 45, Novosibirsk, 630107, Russia |
| 2 | E-mail: bakaev@online.nsk.su |
The purpose of this study was to investigate the effect of atorvastatin calcium in water solutions on the nematode life span. In this experiment atorvastatin calcium was used in following dilutions: 1:104, 1:105, 1:106, 1:107 and 1:108. Three adult animals (3 - 5 days old) were kept in microtitre wells containing 0.5 ml of liquid medium (with E. coli and without atorvastatin calcium) during 4 hours, then they were discarded and newborn larvae were transferred in next wells (without atorvastatin calcium in medium) every day (one worm in one well) beginning from third day. Then, from 3th to 10th day, these worms were transferred every day in next wells containing medium with atorvastatin calcium in any concentration. This investigation was carried out in temperature +21°C and in the darkness.
The obtained results are presented in the following table.
| Concentration of atorvastatin calcium | n | Longevity (days) | |
| Mean±S.E. | Maximal | ||
| Control | 12 | 20.33±1.91 | 27 |
| 1:104 | 12 | 20.42±1.84 | 28 |
| 1:105 | 12 | 20.35±1.87 | 27 |
| 1:106 | 12 | 20.25±1.70 | 28 |
| 1:107 | 12 | 18.50±1.46 | 28 |
| 1:108 | 12 | 21.50±1.70 | 27 |
Conclusion: If atorvastatin calcium solution was applied to C. elegans, it was not able to increase significantly (P>0.05) their mean longevity in comparison with control.