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WormBook is the online text companion to WormBase, the C. elegans model organism database. WormBook contains original reviews on all aspects of C. elegans biology and up-to-date descriptions of technical procedures used to study this animal.

ISSN : 1551-8507

Editor-in-Chief

Martin Chalfie

Professor of Biological Sciences at Columbia University. He specializes in the molecular genetics of neuronal development and function in C. elegans, particularly the molecular basis of mechanosensory transduction. In addition, he introduced the use the GFP as a biological marker. Honors include election to the National Academy of Sciences and the American Academy of Arts and Sciences. As editor-in-chief he is responsible for chairing and maintaining the editorial board. He also works with the editor on the organization and implementation of WormBook.

Editor

Jane Mendel

Senior Research Associate and Lecturer in Biology at the California Institute of Technology. Dr. Mendel has studied C. elegans since 1987 in the laboratory of Paul Sternberg, specializing in the analysis of G-protein mediated signal transduction. She also uses C. elegans to teach a laboratory course in genetics. The editor works with the editor-in-chief, editorial board, authors and software development group to ensure the flow of text and information from the editorial board to final publication in WormBook, as well as coordinates WormBook's activities with WormBase and other databases.

Editorial Board

The WormBook Editorial Board works with the Editor-in-Chief and Editor to determine the content of WormBook, commission authors and contribute their expertise to the review of WormBook submissions.

Victor Ambros

Professor of Genetics at Dartmouth Medical School. He focuses on understanding the temporal control of cell division and cell fate during development and small regulatory RNAs. His Awards include: Newcomb Cleveland Prize (shared) 2003, Am. Assoc. for the Advancement of Science; most outstanding paper published in Science July 2001-June 2002, and the Lewis S. Rosenstiel Award in Basic Medical Science (Brandeis University) 2005.

Philip Anderson

Professor of Genetics at the University of Wisconsin, Madison. He specializes in understanding nonsense mediated mRNA decay in C. elegans.

Thomas Blumenthal

Professor and Chair of the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder. His research includes the understanding RNA biology, gene structure, operons in C. elegans. His Awards include a 1981 Guggenheim Fellowship.

Monica Driscoll

Professor, Department of Molecular Biology and Biochemistry, Rutgers University. Dr. Driscoll's research uses C. elegans as a model system to study developmental neurogenetics and the molecular genetics of neuronal function and dysfunction. Her laboratory addresses questions relating to mechanosensation, neurodegenerative cell death, and aging. Her awards include The Ellison Medical Foundation 2004 Senior Scholar Award in Aging.

David H. A. Fitch

Associate Professor of Biology in the Department of Biology, New York University. His research includes the study of systematics and taxonomy of Rhabditidae (Nematoda), evolution of morphogenesis and molecular evolution. Awards include: 1995 NSF Career Development Award, 2000 Fulbright Fellowship.

Iva Greenwald

Professor in the Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY, and an Investigator with the Howard Hughes Medical Institute. She specializes in developmental genetics and Notch signaling in C. elegans. Awards and honors include: 1998 Promising Investigator Award, Metropolitan Life Foundation, 2001-Editor, Development.

David H. Hall

Professor, Department of Neuroscience, Albert Einstein College of Medicine. Dr. Hall specializes in ultrastructural studies of the nervous system, using C. elegans as a model. He is also Director of The Center for C. elegans Anatomy and is one of the editors of Wormatlas, a C. elegans database for behavioral and structural anatomy.

Jonathan Hodgkin

Professor of Genetics at the University of Oxford. His research focuses on the developmental and molecular genetics of the nematode Caenorhabditis elegans, with particular reference to nematode-bacterial interactions; sex determination, cell lineage and morphogenesis; informational suppression and gene interaction; telomere function; behavioral genetics and neurogenetics; natural variation; gene mapping and genomics. His Awards include: 1990: Elected Fellow of the Royal Society (London), 1993 - 1997: International Research Scholar, Howard Hughes Medical Institute, 2003-2006 Elected President, Genetics Society of Great Britain.

Erik M. Jorgensen

Professor in the Department of Biology at the University of Utah. He specializes in the genetic analysis of neurotransmission in C. elegans. His awards include:2003-2010 Jacob Javits Award, National Institute of Neuronal Disease and Stroke, NIH.

Judith Kimble

Vilas Professor and Howard Hughes Investigator in the Department of Medical Genetics and Department of Genetics at the University of Wisconsin, Madison. She specializes in understanding the regulation of germline development in the nematode Caenorhabditis elegans. Honors and awards include: 2004-05 President of the Society for Developmental Biology, 2000 President of the Genetics Society of America, 1995 National Academy of Sciences, 1995 American Academy of Arts and Sciences, 1994 - present Investigator, Howard Hughes Medical Institute.

Joshua M. Kaplan

Professor in the Department of Genetics at Harvard Medical School. His research focuses on the neurobiology of C. elegans, including G protein regulation of synaptic transmission and Synapse formation and trafficking of synaptic proteins. His awards include Pew Scholar in the Biomedical Sciences, 1994-1998.

James M. Kramer

Professor of Cell and Molecular Biology at Northwestern University Medical School in the Department of Cell & Molecular Biology. He specializes in understanding the cell biology of C. elegans with an emphasis on the extracellular matrix.

Patricia Kuwabara

Professor, Department of Biochemistry, University of Bristol. Dr. Kuwabara uses C. elegans to address questions aimed toward understanding organismal development and physiology. Her interests include how signaling pathways have evolved, how organisms respond to DNA damage, and the role of lipid and protein trafficking in cytokinesis.

Andres Villu Maricq

Professor of Biology and Adjunct Associate Professor of Neurology, Department of Biology, University of Utah. Dr. Maricq is interested in identifying molecules that contribute to synaptic function and behavior in C. elegans. His research includes the investigation of components involved in glutamate receptor function, neuromuscular junction development and function, and the generation and regulation of rhythmic behaviors.

Steven McIntire

Assistant Professor, UCSF Department of Neurology, Gallo Clinic and Research Center. Research in the McIntire lab is focused on the identification of vesicular transporters involved the packaging of neurotransmitters into synaptic vesicles and the genetics of ethanol sensitivity in C. elegans.

Barbara J. Meyer

Investigator for the Howard Hughes Medical Institute, a Professor of Genetics and Development in the Department of Molecular and Cell Biology, at the University of California, Berkeley, and an adjunct Professor in the Department of Biochemistry and Biophysics, U.C. San Francisco School of Medicine. She specializes in understanding the genetics and cell biology of C. elegans with an emphasis on sex determination and dosage compensation. Her awards include: Investigator of the Howard Hughes Medical Institute, 1997-present, The Harvey Society Lecture, 2000, Member, U. S. National Academy of Sciences, elected 2000.

Donald G. Moerman

Professor in the Zoology Department at the at the University of British Columbia. He specializes in understanding the formation and function of muscle in C. elegans. Awards include a 1994-1995 UBC Killam Faculty Reseach Fellowship.

Garth Patterson

Assistant Professor, Department of Molecular Biology and Biochemistry, Rutgers University. Dr. Patterson's research interests include how the TGF-b pathway regulates development in C. elegans.

James R. Priess

Member of the Basic Sciences Division at the Fred Hutchinson Cancer research center, an Investigator with the Howard Hughes Medical Institute and an Affiliate Professor of Zoology at the University of Washington. He specializes in understanding molecular events of early embryonic development using C. elegans as a model system.

Donald Riddle

Professor of Medical Genetics and a member of the Michael Smith Laboratories at the University of British Colombia. Dr. Riddle's research contributes to our understanding of dauer formation, life span genetics, and metabolism in C. elegans.

Geraldine Seydoux

Professor in the Department of Molecular Biology and Genetics at the Johns Hopkins University, School of Medicine. Her research focuses on understanding embryonic polarity and the soma-germline dichotomy using C. elegans as a model system. Her awards include: 1999 Presidential Early Career Award for Scientists and Engineers (PECASE) NIH and a 2001 MacArthur Fellowship.

Lincoln D. Stein (ex officio member)

Professor, Cold Spring Harbor Laboratory. Prior to coming to CSHL in 1998, Lincoln Stein was director of informatics at the MIT/Whitehead Center for Genome Research (WICGR), At CSHL, Dr. Stein has taken on leadership of the Generic Model Organism Database (GMOD) effort, developing software useful for all genome databases. His earlier work was in the design of application programming interfaces (APIs) for Acedb databases, which formed the basis of a collaborative development of a distributed third-party annotation system for the C. elegans genome. He is a core member of the BioPerl project, an international effort to develop bioinformatics software for use with the Perl programming language, and contributed the central Bio::SeqIO, Bio::Graphics, and Bio::DB modules.

Paul W. Sternberg (ex officio member)

Investigator of the Howard Hughes Medical Institute. Dr. Sternberg is also the Thomas Hunt Morgan Professor of Biology at the California Institute of Technology and Adjunct Professor of Cell and Neurobiology at the University of Southern California School of Medicine, Los Angeles. He leads the efforts to coordinate the integration of WormBase and WormBook from the WormBase side. Dr. Sternberg has been in the C. elegans field since 1979, interrupted by 2.5 years working on yeast. He has organized several C. elegans meetings: co-Organizer of the 1995 International Meeting, Organizer of the 1994 West Coast C. elegans Meeting, and Head Organizer of the 2001 International Meeting. Some of his recent work has involved establishing genetics of other rhabditid nematodes.

Susan Strome

Chancellor's Professor in the Department of Biology at Indiana University, Bloomington. She utilizes C. elegans to study how chromatin regulators and cytoplasmic germ granules contribute to specifying and guiding development of the germ line, and on pattern formation in the early embryo, with a focus on the roles of microtubule motors. She was Co-Organizer of the 1987, 1999, and 2001 International C. elegans Meetings, and of the 2006 Germ Cells meeting. Her awards include 1988-90 and 1992-97 American Cancer Society Faculty Awards, and a 1998-99 Guggenheim Fellowship.

WormMethods Editors

Julie Ahringer

Reverse genetics. Wellcome Senior Research Fellow at the Gurdon Institute and Member of the Genetics Department, Cambridge University

Simon J. Boulton

Biochemistry and molecular biology. Researcher, DNA Damage Response Laboratory, London Research Institute

Thomas C. Evans

Transformation and microinjection. Professor, Department of Cellular and Structural Biology, University of Colorado Health Science Center

David Fay

Forward genetics and genetic mapping. Assistant Professor, Department of Molecular Biology, University of Wyoming

Anne Hart

Behavior. Associate Professor, Departments of Pathology and Neurobiology, Massachusetts General Hospital and Harvard Medical School

Oliver Hobert

Gene expression. Associate Professor, Department of Biochemistry, Columbia University

Raymond Lee

Web resources for C. elegans studies. Staff member, WormBase, California Institute of Technology

Ann Rougvie

Development. Associate Professor, Department of Genetics, Cell Biology, and Development, University of Minnesota

William Schafer

Neural imaging and electrophysiology. Associate Professor in the Section of Neurobiology & Computational Neurobiology, University of California at San Diego

Shai Shaham

Methods in cell biology. Strang Assistant Professor, Rockefeller University

Ralf J. Sommer

Methods in nematode species other than C. elegans. Professor, Department for Evolutionary Biology, Max-Planck Institute for Developmental Biology

Albertha J. M. Walhout

Biochemistry and molecular biology. Assistant Professor in the Program in Molecular Medicine and the Program in Gene Function and Expression, University of Massachusetts Medical School

Software Development Group

Daniel Wang

As WormBook Production Manager, Daniel oversees the publication process, ensuring timely handling of chapter production. He is in charge of the website. Daniel is also a WormBase curator.

Todd Harris

Scientific Programmer, Bioinformatics Developer III under Dr. Lincoln D. Stein at Cold Spring Harbor Laboratory. He specializes in bioinformatics, user-interface development, data analysis and visualization.

Igor Antoshechkin

Curator, WormBase. Contributes to user-interface development.

Felicia Carvalho

Technical Production Editor, providing general computational support for WormBook. Felicia is a doctoral student in the Department of Pharmaceutical Sciences, St. John's University, New York.

WormBook Alumni

Eimear Kenny

Maggie Tsang

Cecilia Nakamura

Lisa Girard

Tristan J. Fiedler

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All WormBook content, except where otherwise noted, is licensed under a Creative Commons Attribution License.